Understanding Type 2 Diabetes Mellitus
Noninsulin-dependent Diabetes Mellitus is also popularly referred to as Type 2 Diabetes Mellitus. It is the most common form of this kind of condition. In NIDDM, the pancreatic beta cells produce insulin. Actually, when the blood insulin level is measured, it might be found to be low, normal, or high. However, you will find abnormalities of insulin secretion in conjunction with abnormal responses to insulin in the cellular level.
If you have this kind of metabolic condition, you are not dependent upon exogenous insulin for survival, but may require its administration for optimal charge of hyperglycemia. It is unlikely that the patient will develop ketoacidosis except during unusual periods of stress, for example those caused by severe infections, trauma or surgery.
The presence of elevated blood glucose levels despite the normal levels of insulin indicates that the insulin is not working properly. This condition referred to as insulin resistance and it is the major problem in Type 2 Diabetes. The following might be reasons why this problem occurs.
First of all, there may be a defect within the beta cell. You may lack the first phase of insulin release in reaction to the elevation in the blood sugar level. This defect results in a prolonged rise in the blood sugar levels before this rise can be balanced by the effect of insulin. The prolonged blood sugar elevation serves as a constant stimulus to the secretion of insulin. This can lead to decrease the number of insulin receptors which leads to insulin resistance.
It can also be due to the defect within the uptake of glucose by peripheral tissues. Insulin binds well to the receptor sites, yet the insulin effect is deficient. Thus, the metabolic defects are located beyond the receptor in the metabolic pathway. Even just in the absence of diabetes, obesity causes insulin resistance. This occurs through receptor and post receptor defects. Check out more facts at http://diabetes-type-2.com/.
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